Luco (Pierfrancesco Favino) has abandoned his affluent life as a doctor in Rome, and now works in a ramshackle hospital in Kenya. When his life-long friend Mario surprises him by showing up in Africa to assist him with his new life and career, Luco welcomes the idea of someone familiar - but soon, it becomes apparent that Mario may have had ulterior criminal reasons for hastily leaving Italy. Things are not aided by the additional arrival of Ginevra, Mario's wife, whom Luca has long been in love with.
